Cytokines and beta-cell destruction
نویسنده
چکیده
Several genetic and environmental factors appear to cooperate to precipitate type1 diabetes, a spontaneous autoimmune disease in humans and in the nonobese diabetic (NOD) mouse. NOD mice, like type1 diabetic patients, develop insulitis, an early infiltration of leukocytes into the pancreas that leads to inflammatory lesions within the islets. However, overt type1 diabetes requires the subsequent destruction of the vast majority of insulin producing islet β-cells, a process mediated by activation of autoreactive T-helper type1CD4 and subsequently, CD8 Tcells.
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